Current treatments for gum disease manage symptoms but often lead to bone damage. This study introduces a new method to tackle this issue by using 3D-printed scaffolds that release antibiotics and promote bone regeneration.
Gum disease treatments help control symptoms, but they don't always prevent bone damage. In this study, a new approach using 3D-printed scaffolds that not only fight bacteria but also aid in regrowing bone is explored.
The researchers created scaffolds using Facilan™ PCL 100 Filament with added tetracycline hydrochloride (TCH). These scaffolds were tested for their structure, chemistry, drug release, and ability to fight bacteria. Additionally, tests were done with osteoprecursor cells (MC3T3-E1) to see if the scaffolds encouraged bone cell growth and activity.
The PCL-TCH scaffolds effectively inhibited Staphylococcus aureus (bacteria) and showed promising signs of supporting bone tissue growth. Despite some delays in cell growth, the scaffolds stimulated the production of collagen and demonstrated increased alkaline phosphatase (ALP) activity, essential for bone development.
The study suggests that PCL-TCH scaffolds could be a potential solution for severe gum disease. These 3D-printed implants not only fight bacteria but also create a favorable environment for bone regeneration.
Read the full study here: https://www.mdpi.com/2575550
